On the basis of iron barites sand cementation material, clay was added as the plasticizer and the weight ratio of clay to aggregates plus clay, the weight ratio of iron ore powder plus barite powder to aggregates, the weight ratio of iron ore powder to iron ore powder plus barite powder, and the weight ratio of gypsum to mixture were selected as four factors with five variable levels. Twenty five schemes of the material mixture ratio were designed using orthogonal design method, and related laboratory tests were conducted to obtain physical and mechanical parameters of similar materials such as density, compressive strength, tensile strength, elastic modulus, Poisson’s ratio, internal friction angle and cohesion. Moreover, variations in concerned parameters were analyzed for different material mixture ratios. Based on the analysis above, similar materials of two different real rocks were prepared and two related base friction physical model tests were also carried out. The test results reveal that, 1) the physical and mechanical parameters of the similar materials fabricated according to the similarity ratio proposed in this study vary considerably, which can satisfy the requirement of different kinds of rocks; 2) the influence of each factor on the physical and mechanical parameters of similar material shows good regularity, which facilitates identifications of the optimum mixture ratios for different rock materials; 3) the physical and mechanical parameters of two different materials are consistent with those of the real rocks to a great extent; 4) these two different rock similar materials can be successfully applied in the base friction physical model tests.